Ghanaian-American, Isis Asare is a serial cultural entrepreneur with over a decade of finance and business development experience at Fortune 500 companies such as T-Mobile, Microsoft, Shutterfly, and Amazon. One of her earliest entreprenuerial ventures was Sistah Sinema which started in her living room and expanded to 20 cities across the US and internationally, with a social/email reach of 10,000 points of contact, and online presence with Indieflix within five years. She successfully exited Sistah Sinema by selling it to community investors in 2015.

She went on to officially launched Sistah Scifi 2019 with a celebration of Jewelle Gomez's 25th Anniversary edition of The Gilda Stories. Between 2019 and 2020, Sistah Scifi sales increased tenfold through expanding physical book selection; launching private label shirts, sweatshirts, and bags; and offering audiobooks and ebooks. Sistah Scifi has been featured in The New York Times, Oprah  Magazine, BookRiot, Buzzfeed, VentureBeat, and Facebook's Boost My Business. Sistah Scifi has also hosted author interviews with John Jennings, NK Jemisin, LL McKinney, Jewelle Gomez, and Nisi Shawl to name a few. Sistah Scifi has developed strong collaborations with major international publishers such as Hachette/Orbit, Akashic, Abrams, Macmillan/Tor.com, and Simon and Schuster.